Moodle

Course “Medicinal Chemistry & Drug Design for Bioinformaticians”

Extent: 2 SWS (in the summer term "SoSe") & written exam (graded)

Lecturers: PD Dr. Martin Empting, Dr. Walid Elgaher

Content:

The lecture series will tackle the fundamentals of modern medicinal chemistry including an overview on common pharmaceutical drug targets, pharmacodynamics, structure-activity relationships as well as considerations regarding pharmacokinetics (ADME-T; Absorption, Distribution, Metabolism, Excretion, Toxicology). The students will learn about the different types of assay systems for determining pharmacodynamics and pharmacokinetic parameters. A special focus are the core principles medicinal chemistry optimization applied in the hit-identification, lead generation and lead optimization phases. These include various kinds of hit-finding and screening methodologies, specific effects and characteristics of frequent substituents, bioisosterism, ringtransformations, binding modes, as well as ligand- and structure-based approaches. Finally, methods for quantifying drug-target interactions will be covered.

The lecture series will be held in English.